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In one aspect, the therapeutically effective amount is that which may treat or alleviate the disease or symptoms of the disease at a reasonable benefit/risk ratio applicable to any medical treatment

Pombo M, Leal-Cerro A, Barreiro J, Pealva A, Peino R, Mallo F, Dieguez C, Casanueva FF

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The co-crystallized fragments found in sub-pockets A-C and the protein were used as input for the SZMAP, Gameplan, and vBrood applications and visualization in MOE